The rapid diffusion of artificial intelligence (AI) into religious education, Qur'anic exegesis (tafsir), and da'wah practice raises urgent questions about how classical Islamic epistemology can govern emergent digital technologies. Existing scholarship has largely treated AI governance, exegetical authenticity, and the reconfiguration of religious authority as separate concerns. This paper constructs an integrated Qur'anic ethical framework, anchored in Tawhid, Maqasid al-Shariah, Adl (justice), and Amanah (trust), for evaluating AI's role across Islamic scholarship and education, with particular attention to the Nusantara context and Indonesian State Islamic Higher Education Institutions (PTKI), including IAIN Parepare. Employing a qualitative conceptual-theological method, the study synthesizes recent Scopus-indexed literature (2015–2024) across Islamic studies, AI ethics, digital humanities, and theology, and triangulates this literature with purposive semi-structured interviews conducted with sixteen lecturers and institutional leaders at two Indonesian Islamic higher education institutions, IAIN Parepare and Institut Agama Islam Hamzanwadi (IAIH) Pancor. Findings, corroborated by field interviews, show that algorithmic bias risks decontextualizing Qur'anic meaning; that AI is reshaping religious authority toward hybrid, digitally negotiated figures while lecturers and institutional leaders continue to anchor authority in scholarly transmission and moral exemplarity; that PTKI institutions face both opportunity and risk in adopting AI for religious instruction and currently lack formal governance instruments to manage that risk; and that Islamic theology maintains a firm boundary between AI's mechanistic processing and divine omniscience or human moral agency. The paper argues that AI can be legitimately deployed only as an assistive instrument under sustained human scholarly oversight, and it offers a practical, maqasid-based governance model relevant to PTKI and to Indonesia's broader project of digital transformation in Islamic higher education.